Synthesis of new (benzimidazolyl)piperazines with affinity for the 5-HT1A receptor via Pd(0) amination of bromobenzimidazoles

M L López-Rodríguez; A Viso; B Benhamú; J L Rominguera; M Murcia

doi:10.1016/s0960-894x(99)00384-4

Synthesis of new (benzimidazolyl)piperazines with affinity for the 5-HT1A receptor via Pd(0) amination of bromobenzimidazoles

Bioorg Med Chem Lett. 1999 Aug 16;9(16):2339-42. doi: 10.1016/s0960-894x(99)00384-4.

Authors

M L López-Rodríguez¹, A Viso, B Benhamú, J L Rominguera, M Murcia

Affiliation

¹ Departamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense, Madrid, Spain. mluzlr@eucmax.sim.ucm

PMID: 10476865
DOI: 10.1016/s0960-894x(99)00384-4

Abstract

The synthesis of a new family of (benzimidazolyl)piperazines has been developed through Pd(0) mediated amination of 4- and 6-bromobenzimidazole derivatives. Preliminary studies showed that some of these compounds are potent 5-HT1A receptor ligands.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amination
Animals
Benzimidazoles / metabolism*
Cerebral Cortex / metabolism
In Vitro Techniques
Piperazines / chemical synthesis*
Piperazines / metabolism
Radioligand Assay
Rats
Receptors, Serotonin / metabolism*
Receptors, Serotonin, 5-HT1
Structure-Activity Relationship

Substances

Benzimidazoles
Piperazines
Receptors, Serotonin
Receptors, Serotonin, 5-HT1